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Publications

Adam Belley, Mario Callejo, Francis Arhin, Mohammed Dehbi, Ibtihal Fadhil, Jing Liu, Geoffrey McKay, Ramakrishnan Srikumar, Pascale Bauda, Nhuan Ha, Michael DuBow, Philippe Gros, Jerry Pelletier and Greg Moeck
Competition of bacteriophage polypeptides with native replicase proteins for binding to the DNA sliding clamp reveals a novel mechanism for DNA replication arrest in Staphylococcus aureus.
Molecular Microbiology, Volume 62, Issue 4, November 2006, Page 1132, [doi:10.1111/j.1365-2958.2006.05427.x]

Francis Arhin, Odette Bélanger, Stéphane Ciblat, Mohammed Dehbi, Daniel Delorme, Evelyne Dietrich, Dilip Dixit, Yanick Lafontaine, Dario Lehoux, Jing Liu, Geoffrey A. McKay, Greg Moeck, Ranga Reddy, Yannick Rose, Ramakrishnan Srikumar, Kelly S.E. Tanaka, Daniel M. Williams, Philippe Gros, Jerry Pelletier, Thomas R. Parr, Jr. and Adel Rafai Far
A new class of small molecule RNA polymerase inhibitors with activity against Rifampicin-resistant Staphylococcus aureus.
Bioorganic & Medicinal Chemistry, Volume 14, Issue 17 , 1 September 2006, Pages 5812-5832

Geoffrey A. McKay, Ranga Reddy, Francis Arhin, Adam Belley, Dario Lehoux, Greg Moeck, Ingrid Sarmiento, Thomas R. Parr, Philippe Gros, Jerry Pelletier and Adel Rafai Far.
Triaminotriazine DNA helicase inhibitors with antibacterial activity.
Bioorganic & Medicinal Chemistry Letters, Volume 16, Issue 5, 1 March 2006, Pages 1286-1290.

Tony Kwan, Jing Liu, Michael DuBow, Philippe Gros, and Jerry Pelletier.
Comparative Genomic Analysis of 18 Pseudomonas aeruginosa Bacteriophages.
Journal of Bacteriology, Volume 188, Issue 3, February 2006, Pages 1184-1187.

Yannick Rose, Stéphane Ciblat, Ranga Reddy, Adam C. Belley, Evelyne Dietrich, Dario Lehoux, Geoffrey A. McKay, Hugo Poirier, Adel Rafai Far and Daniel Delorme.
Novel non-nucleobase inhibitors of S. aureus DNA polymerase IIIC.
Bioorganic & Medicinal Chemistry Letters, Volume 16, Issue 4, 15 February 2006, Pages 891-896.

Liu J., Dehbi M., Moeck G., Arhin F., Bauda P., Bergeron D., Callejo M., Ferretti V., Ha N., Kwan T., McCarty J., Srikumar R., Williams D., Wu J.J., Gros P., Pelletier J., DuBow M.
Antimicrobial drug discovery through bacteriophage genomics.
Nat. Biotechnol. 2004 22:185-191.

Kwan T., Liu J., DuBow M., Gros P., Pelletier J..
The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages.
Proc. Natl. Acad. Sci. U.S.A. 2005 102:5174-5179.


Presentations

D. Lehoux, F.F. Arhin, I. Fadhil, K. Laquerre, V. Ostiguy, I. Sarmiento, G. Moeck, A. Rafai Far, T. R. Parr Jr.
Comparative Efficacy of Rifabutin and Gatifloxacin in the Rat Osteomyelitis Model
ASM General Meeting 2007, Toronto, Canada, May 21-24, 2007.

H.S. Heine, J. Bassett, L. Miller, A. Bassett, T. R. Parr, Jr., G. Moeck
Efficacy of Oritavancin in a Murine Model of Bacillus anthracis Spore Inhalation Anthrax
ASM General Meeting 2007, Toronto, Canada, May 21-24, 2007.

F.F. Arhin, I. Sarmiento, T.R. Parr Jr, G. Moeck
Effect of Polysorbate-80 on Oritavancin Binding to Plastic Surfaces – Implications for Susceptibility Testing
17th Annual European Congress of Clinical and Chemotherapy (ICAAC), Munich, Germany, March-April 2007.

F.F. Arhin, I. Sarmiento, A. Belley, G. A. McKay, D. Draghi, P. Grover, D. Sahm, T.R. Parr Jr., and G. Moeck
Influence of Polysorbate-80 on Susceptibility of Gram-positive Bacteria to Oritavancin
17th Annual European Congress of Clinical and Chemotherapy (ICAAC), Munich, Germany, March-April 2007.

D. Lehoux, G.A. McKay , I. Fadhil, K. Laquerre, M. Malouin, V. Ostiguy, G. Moeck, T.R. Parr Jr.
Efficacy of oritavancin in a mouse model of Streptococcus pneumoniae pneumonia
17th Annual European Congress of Clinical and Chemotherapy (ICAAC), Munich, Germany, March-April 2007.

A. Belley, G. A. McKay, I. Fadhil, S. Beaulieu, G. Moeck and T. R. Parr, jr
Oritavancin Kills Staphylococcus aureus in Slow-growing Planktonic and Biofilm States
46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, Sept. 2006.

D. C. Draghi, G. Moeck, C. Thornsberry, D. F. Sahm
Comparative In Vitro Potency of Oritavancin, Teicoplanin, and Vancomycin against Glycopeptide-Susceptible and -Resistant Gram-Positive Organisms
46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, Sept. 2006.

D. Lehoux, F. F. Arhin, I. Fadhil, K. Laquerre, V. Ostiguy, I. Sarmiento, G. Moeck, T. R. Parr jr
Oritavancin Demonstrates Rapid and Sustained Bactericidal Activity in the Rat Granuloma Pouch Model of Staphylococcus aureus Infection
46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, Sept. 2006.

G. A. McKay, I. Fadhil, S. Beaulieu, S. Ciblat, A. Rafai Far, G. Moeck, T. R. Parr jr
Oritavancin Disrupts Transmembrane Potential and Membrane Integrity Concomitantly with Cell Killing in Staphylococcus aureus and Vancomycin-Resistant Enterococci
46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), San Francisco, Sept. 2006.

Geoff McKay.
Discovery of Small Molecule Inhibitors of S. aureus, RNA Transcription
Enzyme Inhibitors and Drug Design Symposia at the 89th Canadian Chemistry Conference and Exhibition, Halifax, NB, May 30, 2006.

Greg Moeck
Antimicrobial Drug Discovery Through Bacteriophage Genomics.
Symposium 190/M (Using Phages to Develop Novel Antimicrobials and Therapies) at the American Society for Microbiology (ASM) 106th General Meeting, Orlando, FL, May 21-25, 2006.

Greg Moeck
Antimicrobial Drug Discovery Through Bacteriophage Genomics.
Department of Microbiology and Immunology, McGill University, Montreal, QC, May 18, 2006.

Greg Moeck
Phage-Inspired Discovery of Small-Molecule Antibiotics.
11th Annual Antibacterial Drug Discovery & Development Summit, Princeton, NJ, April 10-11, 2006.

M. Dehbi, F. Arhin, P. Bauda, D. Bergeron, D. Delorme, E. Dietrich, A. Rafai Far, T. Kwan, J. Liu, J. McCarty, G. Moeck, R. Srikumar, D. Williams, M. DuBow, P. Gros, J. Pelletier.
2005 The Primary Sigma Factor of Staphylococcus aureus: From Target Identification to Isolation of Inhibitors of the RNA Polymerase Holoenzyme.
45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, D.C., December 14-19, 2005.

A. Belley, M. Callejo, F. Arhin, M. Dehbi, I. Fadhil, J. Krishnamoorthy, J. Liu, I. Sarmiento, R. Srikumar, P. Bauda, N. Ha, M. DuBow, P. Gros, J. Pelletier, and G. Moeck.
Bacteriophage Proteins G1ORF240 and TwORF168 Validate the DNA Sliding Clamp of Staphylococcus aureus for Inhibitor Screening.
45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, D.C., December 14-19, 2005.

A. Rafai Far, M. Dehbi, F. Arhin, D. Bergeron, S. Ciblat, D. Delorme, E. Dietrich, D. Dixit, T. Kwan, Y. Lafontaine, J. Latha Krishnamoorty, D. Lehoux, J. Liu, G. McKay, G. Moeck, R. Reddy, Y. Rose, R. Srikumar, K.S.E. Tanaka, D. Williams, P. Gros, and J. Pelletier.
A New Class of Small Molecule RNA Polymerase Inhibitors with Activity Against S. aureus.
45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Washington, D.C., December 14-19, 2005.

Liu, J.
Antibacterial Drug Discovery and Development Summit, Cherry Hill, NJ, March 29-30, 2004.

Moeck, G., Liu, J., Dehbi, M., Arhin, F., Callejo, M., Ha, N., Kwan, T., Srikumar, R., Williams, D., and Wu., J.J.
Impact of Bacteriophage Genomics on Target Identification and Validation for Antibacterial Discovery.
Society for Biomolecular Screening 9th Annual Conference and Exhibition, Portland, Oregon, September 21-25, 2003.

Wu, J.J., J. Liu, M. Dehbi, G. Moeck, F. Arhin, M. Callejo, D. Dixit, N. Ha, T. Kwan, S. Sirois, R. Srikumar, and D. Williams.
Antibacterial discovery using phage-validated, novel targets.
43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Chicago, Illinois, September 14-17, 2003.

Liu, J., Arhin, F., Callejo, M., Dehbi, M., Ha, N., Kwan, T. Moeck, G., Srikumar, R., Williams, D., and Wu., J.J.
From phage genomics to antimicrobial drug discovery.
15th Evergreen Phage Biology Meeting, Olympia, Washington, July 23-27, 2003.

Moeck, G.S., F. Arhin, P. Bauda, D. Bergeron, M. Dehbi, V. Ferretti, N. Ha, T. Kwan, J. Liu, J. McCarty, M. DuBow, P. Gros, and J. Pelletier.
Integration of phage genomics with target identification and HTS-a novel approach to drug discovery.
Society for Biomolecular Screening 8th Annual Conference and Exhibition, The Hague, The Netherlands, September 22-26, 2002.